Population differentiation in allele frequencies of obesity-associated SNPs

Population Attributable Fraction of Hypertension Associated with Obesity in Iran

Introduction: Prevalence of obesity has been increased in Iran over the recent decades. Little is known about fraction of hypertension attributable to obesity in Iran. This study aimed to determine the population attributable fraction (PAF) of hypertension due to obesity across different provinces of Iran. Materials & Method: Data on prevalence of hypertension, were extracted from Iranian Mi...

Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers

MicroRNAs (miRNAs) are a class of noncoding small RNAs that regulate gene expression by base pairing with target mRNAs at the 3'-terminal untranslated regions (3'-UTRs), leading to mRNA cleavage or translational repression. Single-nucleotide polymorphisms (SNPs) located at miRNA-binding sites (miRNA-binding SNPs) are likely to affect the expression of the miRNA target and may contribute to the ...

Allele Frequencies and Genotype Frequencies

PopHist: inferring population history from the spectrum of allele frequencies

SUMMARY PopHist is a computer program that uses the frequency spectrum of alleles to: (a) estimate maximum likelihood parameters describing a population's history; and (b) compare alternative hypotheses about population history using likelihood ratio tests. The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked site...

A measure of population subdivision based on microsatellite allele frequencies.

A new measure of the extent of population subdivision as inferred from allele frequencies at microsatellite loci is proposed and tested with computer simulations. This measure, called R(ST), is analogous to Wright's F(ST) in representing the proportion of variation between populations. It differs in taking explicit account of the mutation process at microsatellite loci, for which a generalized ...